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Target intelligence / Profile preview
TNF receptor associated protein 1 (TRAP1)
- Target
- TRAP1
- Molecular classification
- Heat shock protein 90 (HSP90) family, Molecular chaperone
01
Overview
TRAP1 is a mitochondrial molecular chaperone belonging to the heat shock protein 90 (HSP90) family. It plays a critical role in regulating cellular stress responses, particularly under conditions of oxidative or metabolic stress. Its functions include acting as a molecular chaperone for retinoblastoma protein (Rb), modulating mitochondrial biogenesis, and driving smooth muscle cell senescence in diseases like atherosclerosis. TRAP1 influences key pathways such as cell cycle control and mitochondrial function, with altered expression levels implicated in cancer progression and vascular disease.
02
Biological functions
Regulation of cellular stress responsesMolecular chaperone activityRegulation of apoptosisModulation of mitochondrial biogenesisCell cycle regulation
03
Disease associations
CancerAtherosclerosis
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