TOG array regulator of axonemal microtubules protein 1 (TOGARAM1)

TOG array regulator of axonemal microtubules protein 1 (TOGARAM1) is a microtubule-associated protein that contains multiple TOG (tumor overexpressed gene) domains, which are structurally conserved for tubulin binding and microtubule regulation[1][2]. It is found throughout ciliated eukaryotes and is essential for cilium assembly, structural maintenance, and length regulation by coordinating microtubule polymerization and stabilizing axonemal microtubules, particularly at the ciliary tip and basal body[1][2][5]. Mutations in TOGARAM1 disrupt ciliary structure and function, leading to ciliopathies such as Joubert syndrome (JBTS37) and are implicated in neural tube defects like spina bifida by altering Sonic Hedgehog signaling during embryonic development[3][5]. TOGARAM1 does not currently have known direct drug interactions or applications as a classical therapeutic target, but its dysfunction represents a mechanism in rare genetic and developmental disease[1][3][5].

Other names

FAM179BKIAA0423Crescerin-1crescerinProtein FAM179BJBTS37family with sequence similarity 179 member B