Toll like receptor 12, pseudogene (TLR12P)

Toll like receptor 12, pseudogene (TLR12P) refers to a non-functional gene in humans that corresponds to TLR12. While TLR12 functions as a pattern recognition receptor involved in innate immunity in mice—detecting molecules from pathogens such as *Toxoplasma gondii*—humans lack a functional TLR12 gene and possess only a pseudogene variant, TLR12P[4][10]. Therefore, TLR12P does not encode a functional protein and is not relevant for therapeutic targeting, biomarker development, or drug interaction studies. Most references to "Toll like receptor 12" as an immunological receptor apply to mouse biology not human biology[1][4][10]. Important context: - Human TLRs include TLR1–TLR10 only; TLR11, TLR12, and TLR13 are absent in the human genome apart from pseudogene remnants[4][10]. - Functional information about TLR12 pertains to rodents, not humans. If your interest is specifically in immune receptors, be aware that TLR12P in humans does not have functional equivalence[1][4][10]. Summary: TLR12P is a human pseudogene, not a functional receptor. It is mistakenly treated as a target in some contexts; correct interpretation is that it holds no therapeutic, biomarker, or mechanistic relevance in human biology. In structured annotation, TLR12P should be marked as non-target and flagged as incorrect for therapeutic target purposes[4][10].

Other names

TLR12Ptoll like receptor 12 pseudogene