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Target intelligence / Profile preview
Toll-like receptor 6 (TLR6)
- Target
- TLR6
- Molecular classification
- Pattern Recognition Receptor, Toll-Like Receptor, Type I transmembrane protein
01
Overview
Toll-like receptor 6 (TLR6) is a pattern recognition receptor and a member of the toll-like receptor family. It functions as a heterodimer with TLR2 to recognize diacylated lipopeptides from various pathogens, including Gram-positive bacteria, mycoplasma, fungi, and protozoa. Upon ligand binding, TLR6 initiates intracellular signaling cascades, leading to the activation of NF-kB and the production of pro-inflammatory cytokines, thereby playing a critical role in innate immunity and inflammatory responses. Its involvement in inflammatory diseases and potential as a target in cancer immunotherapy are under investigation.
- Other names
- CD286
02
Mechanism of action
TLR6 agonists stimulate the TLR2/TLR6 heterodimer, leading to MyD88-dependent NF-kB activation and pro-inflammatory cytokine production.
03
Biological functions
Pathogen recognitionActivation of innate immunitySignal transductionInflammatory response
04
Disease associations
InfectionInflammationCancer
05
Safety considerations
Dysregulation can lead to inflammatory diseasesPotential for off-target effects due to TLR family homology
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