Tolloid-like 1 pseudogene

The tolloid-like 1 pseudogene (ENSG00000274551) is a genomic sequence similar to the tolloid-like 1 (TLL1) gene, but contains mutations that prevent it from coding for a functional protein[2][4]. Pseudogenes like this often arise from duplication or retrotransposition events and accumulate mutations over time, leading to non-functionality at the protein level[2][4]. This pseudogene does not perform the enzymatic or developmental roles attributed to its protein-coding counterpart (TLL1), which is an astacin-like metalloprotease involved in heart development[5]. The pseudogene has no established role as a therapeutic target, biomarker, or in mediating drug action.