TOM1-like protein 2 (TOM1L2)

TOM1-like protein 2 (TOM1L2) is a human adaptor protein encoded by the TOM1L2 gene. It contains an N-terminal VHS domain, a GAT domain, and a C-terminal clathrin-binding motif, enabling TOM1L2 to participate in vesicular trafficking and endosomal sorting. TOM1L2 plays a critical role in ciliary signaling by acting as an adaptor for Lys63-linked ubiquitin chains and the BBSome complex, facilitating the removal of ubiquitinated G protein-coupled receptors from cilia. It colocalizes with Golgi compartments and is believed to regulate growth factor-mediated signaling and immune response. Genetic variants in TOM1L2 are implicated in musculoskeletal traits and disease syndromes such as Smith-Magenis syndrome. Knockdown or loss of TOM1L2 in animal models leads to increased susceptibility to infections, tumor development, splenomegaly, abnormal B- and T-cell counts, and impaired humoral immune responses.

Other names

TOM1L2Target of MYB1-like 2 membrane trafficking proteinTOM1-like protein 2target of myb1-like 2 (chicken)TM1L2_HUMAN (UniProt)

Not established; theoretically, drugs influencing TOM1L2 would affect vesicular trafficking, GPCR signaling, and immune response modulation.