TOMM22 pseudogene 2 (TOMM22P2)

TOMM22P2 (TOMM22 pseudogene 2) is a pseudogene located on chromosome Y (chrY:2827982-2828218, human genome build hg38), annotated in GenBank and Ensembl as a non-coding, non-functional sequence with sequence similarity to the protein-coding TOMM22 gene, but does not encode a functional mitochondrial protein[5][7]. Pseudogenes do not produce functional proteins and typically lack regulatory or disease relevance; TOMM22P2 is not considered a receptor, enzyme, transporter, nor a therapeutic target. It is distinct from the functional TOMM22 gene (translocase of outer mitochondrial membrane 22 homolog), which is central to mitochondrial protein import, but TOMM22P2 itself is simply a genomic remnant without biological activity or clinical significance[5][7]. TOMM22P2 should not be confused with the functional mitochondrial import receptor subunit TOM22, officially known as TOMM22, which *is* a validated therapeutic target and biomarker in multiple diseases including cancer[1][2][3][11]. TOMM22P2 is annotated in major genomic databases (NCBI Gene: 100499417; Ensembl: ENSG00000232195) as a pseudogene, though these entries contain no evidence for protein expression or function[5][7]. If you require information on TOMM22 (the functional protein-coding gene and receptor), please clarify, as its molecular and therapeutic relevance is entirely distinct from TOMM22P2.

Other names

TOMM22P2Translocase of outer mitochondrial membrane 22 homolog pseudogene 2