TOMM40 pseudogene 3 (TOMM40P3)

The TOMM40 pseudogene 3 (TOMM40P3) is one of five highly homologous pseudogenes related to the TOMM40 gene in the human genome. While the TOMM40P3 locus produces RNA transcripts in human cell lines and tissues, there is currently no evidence of protein-coding function or direct biological activity. It may regulate TOMM40 transcription levels and provide regulatory RNA species that buffer against transcriptional fluctuations, but its precise biological roles are undefined. TOMM40P3 is not considered a therapeutic target, and no drugs or disease associations are documented. Importantly, TOMM40P3 and other pseudogene RNAs complicate the molecular measurement of TOMM40 itself, as conventional assays often struggle to distinguish true TOMM40 mRNA from pseudogene-derived transcripts. TOMM40 (the canonical protein) is implicated in mitochondrial function and Alzheimer's disease risk, but these findings do not directly extend to TOMM40P3[1][4][5][6].\n\nIf you are seeking a druggable target, focus on Mitochondrial import receptor subunit TOM40 homolog (TOMM40), not TOMM40P3[3][6].

Other names

TOMM40P3TOMM40 pseudogene 3Sometimes listed as one of several TOMM40-related pseudogenes (e.g., TOMM40P1, TOMM40P2, TOMM40P4, etc.)

None known. There is no evidence of drug mechanism of action involving TOMM40P3.