Target intelligence / Profile preview

Tooth Enamel Hydroxyapatite

Molecular classification
Inorganic Mineral, Calcium Phosphate
01

Overview

Tooth enamel hydroxyapatite refers to the primary mineral component of dental enamel, which is the outermost, highly mineralized layer covering the crown of human teeth. This substance is composed mainly of hydroxyapatite crystals—a crystalline form of calcium phosphate (chemical formula: Ca₁₀(PO₄)₆(OH)₂)—that are densely packed and organized into structures called enamel rods or prisms. Its primary function is protective: tooth enamel acts as a barrier shielding underlying dentin and pulp from physical forces, thermal changes, chemical erosion, and microbial attack. While not a direct therapeutic target in the traditional sense, its properties and interactions (e.g., with fluoride) are crucial in dental health and disease.

Other names
Dental Enamel HydroxyapatiteEnamel HydroxyapatiteCa₁₀(PO₄)₆(OH)₂Tooth Hydroxyapatite
02

Mechanism of action

Fluoride promotes the formation of fluorapatite, a more acid-resistant mineral, during remineralization. Synthetic hydroxyapatite integrates into early lesions for partial restoration.

03

Biological functions

Protection of teethStructural component of enamelMaintains tooth hardnessInvolved in demineralizationInvolved in remineralization
04

Disease associations

Caries formation (demineralization)Tooth decay
05

Interacting drugs

Fluoride

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