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The term "tooth structure" is a descriptive, anatomical term encompassing the physical and tissue-based components of the tooth: enamel, dentin, cementum, dental pulp, and periodontal ligament[2][3][1]. Teeth develop through complex molecular and cellular interactions between epithelial and mesenchymal tissues, guided by signaling pathways such as Wnt, BMP, Hedgehog, FGF, Eda, and Hippo[2][1]. Tooth function and health depend on the integrity of these structures; defects in development or homeostasis can result in a variety of dental diseases and malformations[2][3][4]. "Tooth structure" itself is not a drug target; instead, molecular components within tooth tissues (e.g., enamel matrix proteins, dental stem cells, growth factors, signaling receptors) may serve as specific therapeutic targets for dental tissue regeneration, repair, or disease management[2][3][1].
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