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Topoisomerase ATPase Subunit (N/A)

Target: N/A
Molecular classification: Enzyme, ATPase, DNA Topoisomerase subunit

Overview

The topoisomerase ATPase subunit acts as an energy-transducing motor within type II topoisomerases. Its highly conserved structure enables it to bind/hydrolyze nucleotides efficiently while communicating these events through large-scale conformational shifts that orchestrate complex enzymatic reactions central to genome maintenance processes such as decatenation, relaxation/supercoiling control, and chromosome segregation during cell division.

Mechanism of action

Inhibition of ATP hydrolysis, trapping topoisomerase on DNA

Biological functions

ATP hydrolysisDNA topology managementChromosome condensation/decondensationDecatenationSupercoil removal/introduction

Disease associations

CancerOther

Safety considerations

Off-target effectsDrug resistanceCardiotoxicity (for some inhibitors)Secondary malignancies

Interacting drugs

Topoisomerase II inhibitors (e.g., Etoposide, Doxorubicin)

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