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Topoisomerase II beta (TOP2B)
- Target
- TOP2B
- Molecular classification
- Enzyme, Topoisomerase, DNA modifying enzyme
01
Overview
Topoisomerase II beta (TOP2B) is an essential enzyme that modulates the topological states of DNA during various cellular processes. It acts as a key decatenating enzyme, altering DNA topology by binding to two double-stranded DNA molecules, generating a transient double-stranded break in one molecule, passing another intact strand through this break, and then religating the broken strand. It plays a critical role in transcription regulation, chromosome segregation, DNA repair, and cell differentiation. As a therapeutic target, it is exploited by several chemotherapeutic agents, but this use also raises significant safety concerns.
- Other names
- DNA topoisomerase II betaDNA topoisomerase 2-betaTop2 beta
02
Mechanism of action
Inhibits the religation step of the topoisomerase II catalytic cycle, leading to the accumulation of DNA double-strand breaks.
03
Biological functions
Transcription regulationChromosome segregationDNA repair coordinationRegulation of gene expressionDNA decatenation
04
Disease associations
CancerImmune disordersNeurodevelopmental disordersGenomic instability
05
Safety considerations
Secondary malignancies (therapy-related leukemia)CardiotoxicityInduction of DNA damage
06
Interacting drugs
Etoposide
3 more in the full profile.
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