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DNA Gyrase/Topoisomerase IV (Bacterial) (N/A)
- Target
- N/A
- Molecular classification
- Enzyme, Topoisomerase, Type II Topoisomerase
01
Overview
DNA gyrase and topoisomerase IV are type II topoisomerases found in bacteria, essential for managing DNA topology during replication and cell division. DNA gyrase introduces negative supercoils and removes positive supercoils ahead of the replication fork. Topoisomerase IV decatenates interlinked daughter chromosomes and relaxes positive supercoils behind the replication fork. Both enzymes are heterotetramers and are targeted by quinolone antibiotics.
- Other names
- DNA GyraseTopoisomerase IVBacterial DNA GyraseBacterial Topoisomerase IV
02
Mechanism of action
Quinolones trap enzyme-DNA cleavage complexes, inhibiting DNA synthesis and leading to cell death.
03
Biological functions
DNA supercoilingDNA decatenationDNA relaxationChromosome segregationDNA replicationMaintenance of chromosome structure
04
Disease associations
Infection
05
Safety considerations
Development of bacterial resistanceOff-target effects of quinolones
06
Interacting drugs
Quinolones
1 more in the full profile.
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