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Target intelligence / Profile preview
Topoisomerase IV ATPase Subunit
- Molecular classification
- Enzyme, ATPase, Topoisomerase
01
Overview
The Topoisomerase IV ATPase subunit, commonly referred to as ParE in bacteria such as *Escherichia coli*, is a critical component of the bacterial type II topoisomerase enzyme complex known as topoisomerase IV. This enzyme plays an essential role in DNA replication and chromosome segregation by utilizing the energy from ATP hydrolysis to alter DNA topology, specifically decatenating (unlinking) newly replicated chromosomes and relaxing supercoiled DNA.
- Other names
- ParETopoisomerase IV subunit B
02
Mechanism of action
Inhibition of ATP binding and hydrolysis, preventing DNA strand passage
03
Biological functions
ATP hydrolysisChromosome decatenationSupercoil relaxationDNA binding
04
Disease associations
Infection
05
Safety considerations
Potential for off-target effects on other ATPasesDevelopment of bacterial resistance
06
Interacting drugs
Novobiocin
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