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Topoisomerase IV ATPase Subunit (None)

Target: None
Molecular classification: Enzyme, ATPase, Topoisomerase

Overview

The Topoisomerase IV ATPase subunit, commonly referred to as ParE in bacteria such as *Escherichia coli*, is a critical component of the bacterial type II topoisomerase enzyme complex known as topoisomerase IV. This enzyme plays an essential role in DNA replication and chromosome segregation by utilizing the energy from ATP hydrolysis to alter DNA topology, specifically decatenating (unlinking) newly replicated chromosomes and relaxing supercoiled DNA.

Other names: ParETopoisomerase IV subunit B

Mechanism of action

Inhibition of ATP binding and hydrolysis, preventing DNA strand passage

Biological functions

ATP hydrolysisChromosome decatenationSupercoil relaxationDNA binding

Disease associations

Infection

Safety considerations

Potential for off-target effects on other ATPasesDevelopment of bacterial resistance

Interacting drugs

Novobiocin

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