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Target intelligence / Profile preview
DNA topoisomerase 4 subunit A (ParC)
- Target
- ParC
- Molecular classification
- Enzyme
01
Overview
DNA topoisomerase 4 subunit A, also known as ParC, is a protein component of the bacterial enzyme topoisomerase IV. This enzyme is essential for chromosome segregation during cell division in bacteria. It is a target for quinolone antibiotics.
- Other names
- TopoIVTopoisomerase IV subunit AparC gene product
02
Mechanism of action
Inhibition of DNA topoisomerase IV, leading to failure in chromosome segregation and bacterial cell death
03
Biological functions
Chromosome segregationDecatenationRelaxation of supercoiled DNA
04
Disease associations
Infection
05
Safety considerations
Development of antibiotic resistance
06
Interacting drugs
Ciprofloxacin
1 more in the full profile.
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