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Target intelligence / Profile preview
Torsin-1A-interacting protein 2 (TOR1AIP2)
- Target
- TOR1AIP2
- Molecular classification
- Other (type II integral membrane protein; ATPase cofactor)
01
Overview
Torsin-1A-interacting protein 2 (TOR1AIP2) is a type II integral membrane protein primarily located in the endoplasmic reticulum (ER) and acts as a cofactor for the ATPase TorsinA, influencing its distribution between the ER and the nuclear envelope[1][9][8][2]. One isoform of the protein is responsive to interferon alpha, though its role in that context remains to be clarified[8]. TOR1AIP2 is implicated in maintaining ER integrity and modulating ATPase activity, and genetic defects in TOR1AIP2 are linked to neuromuscular disorders, including primary dystonia and specific myopathies[1][8]. There are no known drugs or therapeutic agents directly targeting this protein[1][9][8].
- Other names
- IFRG15LULL1NET9interferon-responsive protein 15interferon responsive gene 15torsin A interacting protein 2lumenal domain-like LAP1isoform IFRG15LOC1635901110020D10RikA130072J07
02
Biological functions
Maintenance of endoplasmic reticulum integrityRegulation of TorsinA distribution between ER and nuclear envelopeATPase activator activityResponse to interferon alpha
03
Disease associations
Neuromuscular disease (e.g., early onset primary dystonia)Myopathy (autosomal recessive, with rigid spine and distal joint contractures)Muscular dystrophy (limb-girdle, autosomal recessive type 2)
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