Torsin family 1 member B (TOR1B)

TOR1B encodes a member of the **AAA+ ATPase family**, a group of ATP-hydrolyzing enzymes essential for diverse cellular processes. The protein localizes mainly to the nuclear envelope and endoplasmic reticulum, where it acts as a chaperone to maintain membrane integrity and support protein folding. It shares high similarity and possible functional redundancy with its paralog, TOR1A, and is notably expressed in neural tissues, suggesting roles in synaptic function and neuronal development. Recent research implicates **TOR1B in cancer biology**, especially in aggressive breast cancer subtypes, where its overexpression is associated with poor prognosis and metastatic potential. It also has a genetic link to idiopathic dystonia in tandem with TOR1A. While no targeted drugs are approved for TOR1B, its function as a chaperone and mediator of cellular stress responses makes it a candidate for future therapeutic intervention and a promising biomarker in oncology[1][3][4][5].

Other names

Torsin-1BDQ1FKSG18MGC4386Torsin ATPase-1BTorsin B

Not established—targeted modulation could impact ATPase activity, protein folding, and cellular stress responses