Torsin family 4 member A (TOR4A)

Torsin family 4 member A (TOR4A) is a human protein encoded by the TOR4A gene located on chromosome 9. It is part of the AAA+ (ATPases Associated with diverse cellular Activities) protein superfamily and is predicted to have ATP binding and ATP hydrolysis activities[9][10][1]. TOR4A is primarily localized in the cytoplasm, endomembrane system, endoplasmic reticulum lumen, and nuclear envelope[1][5]. Its precise biological function in humans is not well defined, but as a member of the torsin family, it may play a role in intracellular trafficking, membrane dynamics, or cellular stress responses—a general property of torsin/AAA+ proteins. There is currently no evidence that TOR4A is a therapeutic target, is implicated in major disease roles, or interacts with known drugs[9][10][6]. Essential context and curation details: - The canonical name is "Torsin family 4 member A" (not "torsin-4A" or "C9orf167"); the most widely accepted abbreviation is TOR4A[9][10]. - Aliases include Torsin-4A, C9orf167, FLJ20245, and torsin family protein C9orf167[9][10]. - Protein family: It belongs to the AAA+ ATPase family and contains P-loop nucleoside triphosphate hydrolase domains[1][6]. - Function & localization: The protein binds and hydrolyzes ATP, with localization to the endoplasmic reticulum and nuclear envelope, similar to other torsin proteins[1][5]. - Disease relevance: No direct implication in major disease pathways, no well-established disease roles, and not a recognized biomarker or therapeutic target as per current literature and databases[9][10][6]. - Interactions/drugs/mechanism/safety: No documented interacting drugs, mechanisms of drug action, or specific safety concerns; these sections remain null or unknown based on current data. Limitations: There are limited functional and clinical data on TOR4A in the public domain. As of this search, most annotations are based on homology, predicted structure, and broad protein family classification[10][9][1][6]. No information supports TOR4A as a regulatory receptor, enzyme, or direct therapeutic target. References used for curation: Information has been synthesized from UniProt, NCBI Gene, EMBL-EBI InterPro, Alliance Genome Resources, and The Human Protein Atlas[10][9][6][1][5][2].

Other names

Torsin-4AC9orf167FLJ20245torsin family protein C9orf167