Tousled like kinase 2 pseudogene 1 (TLK2P1)

Tousled like kinase 2 pseudogene 1 (TLK2P1) is a pseudogene: a genomic DNA sequence similar to a functional gene but typically nonfunctional and noncoding for protein due to mutations or truncations[1]. TLK2P1 shares sequence similarity with the Tousled like kinase 2 (TLK2) gene, which is involved in chromatin assembly and the DNA damage response, but TLK2P1 itself does not encode a functional protein and currently has no established biological function or disease association as a therapeutic target[1]. TLK2P1 is categorized specifically as a pseudogene, not a protein-coding gene or therapeutic target[1]. It is distinct from TLK2 (Tousled like kinase 2), which is a functional serine/threonine kinase with known roles in DNA repair and chromatin assembly[3][7]. No evidence supports TLK2P1 being targeted by drugs, involved in disease, or used as a biomarker. The name "Tousled like kinase 2 pseudogene 1" is correct, but as a pseudogene, it is generally not included among actionable drug targets. There is nothing apparently misspelled about the target's name, but it is not a therapeutically relevant entity, and treating it as a drug or biomarker target is incorrect[1].

Other names

TLK2ps1TLK2P1