Toxic soluble amyloid oligomer (α-sheet conformation)

Toxic soluble amyloid oligomers adopting an α–sheet conformation represent a structurally distinct class of pathogenic aggregates central to neurodegenerative disease mechanisms. These small, non-fibrillar aggregates of amyloidogenic proteins form early in amyloidosis and are highly toxic, strongly implicated as the primary pathogenic species in diseases like Alzheimer's. The α-sheet is a distinct protein secondary structure featuring alternating backbone dihedral angles, resulting in an extended sheet-like arrangement with unique hydrogen bonding patterns. Targeting this α-sheet conformation with de novo designed peptides offers a promising strategy for broad-spectrum inhibition across different amyloid diseases.

Other names

Amyloid oligomers (α-sheet conformation)α-sheet amyloid oligomersToxic amyloid oligomersSoluble amyloid oligomers

Inhibition of aggregation, neutralization of toxicity