Target intelligence / Profile preview

Tp0751 Protein (Pallilysin)

Target: Pallilysin
Molecular classification: Lipocalin, Adhesin, Protease, Surface Protein

Overview

Tp0751, also known as Pallilysin, is a surface-exposed protein from Treponema pallidum that functions as an adhesin and protease. It binds to ECM proteins and the 67-kDa laminin receptor (LamR) on endothelial cells, facilitating bacterial dissemination. Tp0751 is considered a virulence factor and a potential therapeutic target.

Other names: Tp0751Pallilysin

Mechanism of action

Inhibition of adhesion to ECM components and endothelial receptors; Inhibition of protease activity

Biological functions

AdhesionExtracellular matrix bindingProteolysisHost cell interactionImmune evasion

Disease associations

InfectionSyphilisBacterial disseminationTissue invasion

Safety considerations

Potential for off-target effects on ECM degradationRisk of exacerbating inflammatory responses

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