TP53RK binding protein pseudogene 1 (TPRKBP1)

TPRKBP1 is a **pseudogene** corresponding to the TP53RK binding protein (TPRKB), sometimes misattributed as a functional protein target[1]. Pseudogenes are genomic DNA sequences similar to genes but are not translated into functional proteins. TPRKBP1 does not have characterized protein products, molecular function, or therapeutic relevance. By contrast, the related protein **TPRKB** is part of the EKC/KEOPS complex, which is essential for tRNA modification (specifically t6A modification)[3][5][6]. TPRKB has been identified as a specific vulnerability in TP53-deficient cancers, and research is ongoing into its role in cell proliferation, cell cycle regulation, and apoptosis linked to TP53 status[3][5][6]. However, TPRKBP1 on its own does not encode protein, is not a therapeutic target, and has no direct molecular, mechanistic, or disease relevance. **Critical Note**: - If the intention is to reference a druggable or molecular target for cancer therapies, the correct entity is the protein **TP53RK binding protein (TPRKB)**, not the pseudogene TPRKBP1[1][3][5][6]. - The canonical abbreviations and aliases above follow usage in gene databases; for research or clinical applications, always check if the reference is to the functional protein, not a pseudogene. **Summary**: **TPRKBP1** is a pseudogene and not an approved therapeutic target, nor does it encode a functional protein. Any structured database or drug discovery query should use **TPRKB (TP53RK binding protein)** for molecular, disease, and pharmacological context[1][3][5][6].

Other names

TP53RK binding protein pseudogene 1TPRKBP1