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TP53RK binding protein pseudogene 2 (TPRKBP2) is a human genomic element annotated as a pseudogene. Pseudogenes are non-functional sequences related to known genes—in this case, the TP53RK binding protein (TPRKB), which is an established protein involved in cellular translational regulation and cancer biology[1][3][4][5][6]. TPRKBP2 does not encode a functional protein and, as such, is not implicated in any cellular processes, disease mechanisms, or therapeutic strategies. Attention in the literature is focused on the *TP53RK* gene (encoding p53-related protein kinase) and *TPRKB* (encoding TP53RK binding protein), both of which have well-defined roles in the KEOPS/EKC complex necessary for tRNA modification and may be relevant targets in cancer research—but not TPRKBP2 itself[1][3][4][5][6].
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