TP73 antisense RNA 1 (TP73-AS1)

TP73 antisense RNA 1 (TP73-AS1, sometimes called KIAA0495 or PDAM) is a long non-coding RNA transcribed antisense to the TP73 gene at human chromosome 1p36.32. It acts primarily as a microRNA sponge, efficiently binding and sequestering human-specific miR-941 and other microRNAs such as miR-200, thereby modulating post-transcriptional gene regulation involved in cell migration, proliferation, and tumorigenesis. High expression of TP73-AS1 has been linked to adverse clinical outcomes and increased tumor grade in cancers such as glioma. TP73-AS1 holds promise as a biomarker for diagnosis and prognosis, and though not a conventional drug target (such as a receptor or enzyme), it represents a novel regulatory RNA molecule of increasing therapeutic interest in the context of oncology.

Other names

TP73-AS1KIAA0495PDAM (p53-dependent apoptosis modulator)

Not directly drugged; mechanism is via acting as a sponge for specific microRNAs, thereby regulating the downstream expression of their targets (e.g., tumor suppressors or oncogenes)