TP73 antisense RNA 2 (TP73-AS2)

TP73 antisense RNA 2 (TP73-AS2) is a long non-coding RNA (lncRNA) gene transcribed from the antisense strand of the TP73 locus at chromosome 1p36.32 in humans[2]. TP73-AS2 belongs to a family of antisense lncRNAs that regulate the expression or activity of their sense gene partners, especially TP73, a member of the tumor suppressor p53 gene family. Although less characterized compared to the closely related TP73-AS1, TP73-AS2 is believed to exert regulatory effects on gene expression, possibly influencing cellular processes such as proliferation, apoptosis, and response to chemotherapy—mainly in the context of tumor biology[2]. Aberrant expression of antisense natures of the TP73 locus, including TP73-AS2, is increasingly recognized as a feature of diverse human cancers, suggesting potential utility as a biomarker or therapeutic target, but direct drug interventions have not yet been developed. *Note: The provided literature largely focuses on TP73-AS1, but the description and categorization for TP73-AS2 are inferred based on known antisense RNA functions at the TP73 locus and available database summaries. There is no evidence of misnaming or other correctness issues with TP73-AS2, though much less is known about it relative to TP73-AS1.*

Other names

RP5-1092A11.2TP73-AS2

Not applicable for drugs