TPA-induced transmembrane protein (TTMP)

TPA-induced transmembrane protein (TTMP, encoded by C3orf52) is a single-pass transmembrane protein localized primarily to the endoplasmic reticulum and possibly the plasma membrane[4][1]. It plays a crucial role in the LIPH-mediated synthesis of 2-acyl lysophosphatidic acid (LPA), a bioactive lipid important in hair formation and growth[1][13]. Pathogenic variants in C3orf52 are associated with hereditary hypotrichosis 15, a condition characterized by abnormal hair loss[1][9]. TTMP is upregulated in response to TPA, a tumor promoter, and experimental overexpression in cancer cells results in cell cycle arrest in the G0/G1 phase through modulation of the retinoblastoma (Rb) pathway, thereby inhibiting proliferation[2][4]. To date, TTMP is not considered an established therapeutic target, and there are no approved drugs known to interact with this protein. The primary research and disease associations to date relate to rare monogenic hair disorders and experimental cancer biology.

Other names

Chromosome 3 open reading frame 52C3orf52FLJ23186HYPT15Novel endoplasmic reticulum transmembrane proteinTPA induced trans-membrane proteinTTMP