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Target intelligence / Profile preview
TraB domain containing 2B (TRABD2B)
- Target
- TRABD2B
- Molecular classification
- Enzyme, Metalloprotease, Other (Wnt-protein binding protein)
01
Overview
TraB domain containing 2B (TRABD2B) is a membrane-associated metalloprotease that binds Wnt proteins and negatively regulates the Wnt signaling pathway by cleaving the N-terminal residues of a subset of Wnt proteins, such as WNT3A and WNT5, leading to their inactivation through oxidation and oligomerization. Its biological role includes modulation of cell signaling important in development and tissue homeostasis. TRABD2B is expressed in several tissues and its dysfunction is associated with certain developmental disorders, but there is no evidence it is a current therapeutic target or interacts with approved drugs[3][2][1][7].
- Other names
- Metalloprotease TIKI2TIKI2Heart, kidney and adipose-enriched transmembrane protein homologTRAB domain-containing protein 2BUPF0632 protein A
02
Biological functions
Negative regulation of Wnt signaling pathwayWnt-protein bindingProteolysis (metalloendopeptidase activity)Positive regulation of protein oxidationPositive regulation of protein-containing complex assembly
03
Disease associations
Other (associated with hypoplastic right heart syndrome) [note: only limited disease connection identified]
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