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Target intelligence / Profile preview
Trace Amine-Associated Receptor 1 (TAAR1)
- Target
- TAAR1
- Molecular classification
- G protein-coupled receptor, GPCR, Receptor
01
Overview
Trace amine-associated receptor 1 (TAAR1) is a G protein-coupled receptor (GPCR) primarily activated by trace amines. It is a key modulator of monoaminergic neurotransmission, with significant roles in the central nervous system (CNS) and peripheral organs. TAAR1 regulates neurotransmitter systems by modulating dopaminergic, serotonergic, and glutamatergic signaling pathways. Activation of TAAR1 has antipsychotic-like effects and reduces rewarding/reinforcing properties of drugs, making it a potential therapeutic target for schizophrenia and addiction.
- Other names
- TA1TAR1TRAR1Trace amine associated receptor 1Trace amine receptor
02
Mechanism of action
Modulates monoaminergic neurotransmission by activating Gs and Gq proteins, leading to changes in cyclic AMP levels and downstream signaling pathways. Activation can inhibit or fine-tune dopamine transmission.
03
Biological functions
Signal transductionNeurotransmission modulationModulation of dopaminergic signalingModulation of serotonergic signalingModulation of glutamatergic signaling
04
Disease associations
SchizophreniaAddictionMood disordersCognitive dysfunctionNeuropsychiatric disorders
05
Safety considerations
Potential for off-target effects due to broad neuromodulatory actions.Therapeutic challenges related to achieving selective TAAR1 agonism without affecting other receptors.
06
Interacting drugs
Tyramine
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