Trace amine-associated receptor 8 (TAAR8)

Trace amine-associated receptor 8 is an orphan G protein-coupled receptor (GPCR), part of the trace amine receptor cluster located on chromosome 6 in humans. TAAR8 is primarily expressed in the brain, including astroglial cells, and functions as a specific olfactory receptor for trace amine compounds—small amine molecules such as putrescine found in animal body fluids. Ligand binding to TAAR8 triggers conformational changes that activate signaling via G alpha proteins, which are likely G(i)/G(o) subtypes. While related members of the TAAR receptor family mediate diverse functions in olfaction and neuromodulation, the exact endogenous ligands and clinical significance of TAAR8 remain uncertain. Diseases associated with TAAR8 include hereditary essential tremor and N syndrome, suggesting a possible neuromodulatory role, but no approved drugs target TAAR8 specifically.

Other names

TAAR8GPR102TA5TAR5TRAR5TaR-8Trace amine receptor 8TaR-5Trace amine-associated receptor 8G-protein coupled receptor 102trace amine receptor 5

Activation by trace amines or putrescine leads to conformational change and signal transduction through G alpha proteins, likely G(i)/G(o)-coupled signaling pathways