TRAF-interacting protein with FHA domain-containing protein B (TIFAB)

TIFAB is a protein homologous to TIFA, but with truncated N- and C- terminal regions. It binds directly to TIFA and inhibits TIFA-mediated activation of NF-κB—a key pathway in innate immunity and inflammation—by blocking the formation of TIFA-TRAF6 signaling complexes[1][3]. While TIFA itself is a hub for immune activation and DNA damage response, TIFAB serves as a negative regulator, modulating the extent and duration of these signals. Thus, TIFAB is best thought of as a protein modulator within immune signaling networks rather than as a classical receptor, drug target, or enzyme[1][3].

Other names

TIFABTIFA-like proteinTIFA-related protein TIFABTRAF-interacting protein with forkhead-associated domain family member B

Inhibits TIFA-triggered TRAF6 signaling and downstream NF-κB activation by binding to TIFA and blocking its oligomerization or activity[1][3].