TRAF-type zinc finger domain-containing protein 1 (TRAFD1)

TRAF-type zinc finger domain-containing protein 1 (TRAFD1, also known as FLN29) is encoded by the human TRAFD1 gene and characterized by the presence of a TRAF-type (C2H2) zinc finger domain[1][6]. It functions as a negative feedback regulator in the innate immune system, suppressing excessive responses to viral and microbial infection[3][7][8]. TRAFD1 regulates both Toll-like receptor 4 (TLR4) and RIG-I-like helicase (RLH) pathways, primarily by interacting with and inhibiting TRAF6, which dampens NF-κB activation and thus limits proinflammatory signaling[3][7]. It also influences vesicle trafficking, acidification, and resorption in osteoclasts by partnering with proteins like Plekhm1, affecting processes relevant to bone metabolism and disorders such as osteopetrosis and osteopenia[2]. TRAFD1’s regulatory activity makes it important in maintaining immune homeostasis and various physiological pathways relating to inflammation and bone remodeling. There are no known drugs that directly target TRAFD1, nor is it established as a common drug target or biomarker at this time[3][7][8].

Other names

TRAFD1FLN29TRAF-type zinc finger domain containing 1TRAF-type zinc finger domain-containing protein 1FLN29 gene productProtein FLN29