TRAF3-interacting protein 1 (TRAF3IP1)

TRAF3-interacting protein 1 (TRAF3IP1) is a cytoplasmic protein that interacts with TNF receptor-associated factor 3 (TRAF3) and tethers it to cytoskeletal microtubules. TRAF3IP1 also acts as an inhibitor of the innate type I interferon (IFN) response and suppresses interleukin-13 (IL-13) signaling by binding to the interleukin-13 receptor alpha 1 (IL13RA1). It recruits TRAF3 and DISC1 to microtubules, playing a key role in epithelial morphogenesis, kidney development, ciliogenesis, and the regulation of microtubule cytoskeleton organization and stability via MAP4. Mutations in this gene are linked to Senior-Loken syndrome 9 and specific ciliopathies, highlighting its importance in cellular architecture and signaling[1][3][6][7][8]. Notes: - TRAF3IP1 is not currently considered a primary therapeutic target such as a receptor, enzyme, transporter, or typical drug target[1][3][8]. - No drugs, biomarkers, or established safety concerns are associated with this protein in standard reference sources as of the current knowledge base[1][3][8].

Other names

Microtubule-interacting protein associated with TRAF3Intraflagellar transport protein 54 homologIFT54MIP-T3MIPT3DKFZP434F124FAP116CFAP116SLSN9Interleukin-13 receptor alpha 1-binding protein 1Interleukin 13 receptor alpha 1-binding protein-1TNF receptor-associated factor 3 interacting protein 1Microtubule interacting protein that associates with TRAF3