TRAF3IP2 antisense RNA 1 (TRAF3IP2-AS1)

TRAF3IP2 antisense RNA 1 (TRAF3IP2-AS1) is a long non-coding antisense RNA predominantly located in the nucleus. It functions as a tumor suppressor in various contexts, particularly in NONO-TFE3 translocation renal cell carcinoma (NONO-TFE3 tRCC). TRAF3IP2-AS1 regulates gene expression via two primary mechanisms: (1) it promotes decay of PARP1 mRNA (an oncogenic factor) by direct binding and recruitment of the m^6A methyltransferase complex, reducing PARP1 levels; (2) it acts as a competing endogenous RNA (ceRNA), sponging microRNAs (miR-200a-3p, miR-153-3p, miR-141-3p) to prevent downregulation of the tumor suppressor PTEN. Reduced TRAF3IP2-AS1 expression is associated with increased cellular proliferation, migration, and invasion, while its overexpression induces cell apoptosis and restrains tumorigenic activities. Thus, TRAF3IP2-AS1 is implicated as a potential biomarker and novel therapeutic target, although no specific drugs targeting it are clinically available[1][2][4][6].

Other names

C6UASBetaFAARBeta-cell function and apoptosis regulatorC6orf3NCRNA00248TRAF3IP2-AS2

Not directly drug-targeted, but acts by binding to and destabilizing PARP1 mRNA through m^6A methylation; Acts as a molecular sponge for miR-200a-3p, miR-153-3p, and miR-141-3p, impacting PTEN levels[1][2].