Trafficking protein particle complex subunit 10 (TRAPPC10)

Trafficking protein particle complex subunit 10 (TRAPPC10) is a specific subunit of the transport protein particle (TRAPP) II complex, a conserved multisubunit tethering complex essential for vesicle-mediated trafficking in eukaryotic cells. TRAPPC10 is a transmembrane protein localized to the cis-Golgi network and functions primarily in late Golgi trafficking by acting as a membrane tether, facilitating vesicle docking and fusion events critical for ER-to-Golgi and intra-Golgi transport. It participates in the organization of the Golgi apparatus and is necessary for proper secretory pathway function. Multiple alternatively spliced mRNA variants exist, with possibly tissue-specific roles. Pathogenic variants in TRAPPC10 have been implicated in severe neurodevelopmental disorders, including microcephalic syndromes in humans and mice[1][2][3][4][5][6]. There are currently no characterized pharmacological inhibitors or drugs directly targeting TRAPPC10, and it is not a common direct therapeutic target.

Other names

EHOC1TMEM1EHOC-1TRAPP subunit TMEM1TRS130Epilepsy holoprosencephaly candidate 1 proteinProtein GT334Trafficking protein particle complex subunit TMEM1Transport protein particle subunit TMEM1Trafficking protein particle complex subunit 130TRAPP 130 kDa subunitGT334NEDMISSTRS30