Trafficking protein particle complex subunit 12 (TRAPPC12)

Trafficking protein particle complex subunit 12 (TRAPPC12) is an essential subunit of the TRAPPIII complex, which modulates COPII vesicle assembly at endoplasmic reticulum (ER) exit sites to ensure efficient transport from the ER to the Golgi. It is also enriched in the ER–Golgi intermediate compartment. Beyond its central role in vesicle trafficking, TRAPPC12 directly participates in chromosome congression, kinetochore assembly, and recruitment of CENP-E during mitosis. Mutations in TRAPPC12 disrupt Golgi organization, delay ER-to-Golgi protein trafficking, and cause defects in mitotic progression, as well as ciliogenesis, contributing to the development of severe childhood encephalopathy with a constellation of neurodevelopmental deficits. TRAPPC12 is not a classic drug target such as a receptor, enzyme, or transporter, and there are currently no known drugs or targeted mechanisms of action. It is primarily studied for its fundamental roles in cellular trafficking and human neurodevelopmental disease.

Other names

TRAMMTTC15CGI-87PEBASTTC-15TPR repeat protein 15Tetratricopeptide repeat protein 15Tetratricopeptide repeat domain 15trafficking of membranes and mitosis