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Trafficking protein particle complex subunit 13 (TRAPPC13)
- Target
- TRAPPC13
- Molecular classification
- Other (component of multi-subunit tethering complex; vesicle trafficking protein complex)
01
Overview
Trafficking protein particle complex subunit 13 (TRAPPC13) is a component of the multi-subunit TRAPP (trafficking protein particle) complex, specifically associated with the mammalian TRAPPIII subcomplex, involved in the regulation of vesicle-mediated transport from the endoplasmic reticulum (ER) to the Golgi apparatus, vesicle coating and tethering, as well as autophagy, especially in response to cellular stress. TRAPPC13 binds to other TRAPP subunits (such as TRAPPC2L, TRAPPC3, TRAPPC8, and TRAPPC4) and participates in vital processes required for secretory pathway integrity, autophagy flux, and resistance to certain types of cellular stress. While mutations or loss of function can impact cell survival under stress and increase susceptibility to pathogen infection, TRAPPC13 is not a therapeutic drug target or receptor, and no drugs targeting this protein are known[1][2][3][7][8].
- Other names
- C5orf44FLJ13611MGC48585Trs65-relatedSHLD3REV7-interacting novel NHEJ regulator 1UPF0533 protein C5orf44TPC13
02
Mechanism of action
Not applicable (no known direct drug interactions)
03
Biological functions
Endoplasmic reticulum to Golgi vesicle-mediated transportVesicle coatingVesicle tetheringAutophagy
04
Disease associations
Developmental disorders (e.g., Binocular vision disease, Developmental dysplasia of the hip 1)Infectious disease (modulates susceptibility to infection, e.g., *Shigella flexneri* survival during Golgi stress)
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