Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Trafficking protein particle complex subunit 14 (TRAPPC14)
- Target
- TRAPPC14
- Molecular classification
- Other (specific subunit of the multiprotein TRAPPII complex), Microtubule-associated protein
01
Overview
Trafficking protein particle complex subunit 14 (TRAPPC14), also known as microtubule-associated protein 11 (MAP11), is a subunit of the TRAPPII multiprotein complex that plays a specialized role in intracellular membrane trafficking, particularly late Golgi transport and ciliogenesis. TRAPPC14 mediates the trafficking of preciliary vesicles to the mother centriole and is involved in cell population proliferation and alpha-tubulin binding. TRAPPC14 is dispensable for TRAPPII complex integrity but is necessary for Rabin8-mediated ciliation. Mutations in TRAPPC14 have been implicated in autosomal recessive microcephaly[1][2][3][4][5][7][9].
- Other names
- C7orf43MAP11FLJ10925Microtubule-associated protein 11MCPH25trafficking protein particle complex 14uncharacterized protein C7orf43
02
Biological functions
Cilium assemblyRegulation of cell population proliferationAlpha-tubulin bindingMembrane trafficking, including late Golgi traffickingModulation of transcriptional regulator YAP1 activity
03
Disease associations
Microcephaly 25, Primary Autosomal Recessive (associated with mutations)Other neurodevelopmental abnormalities (rare reference)
Beyond the preview
Go deeper on Trafficking protein particle complex subunit 14 (TRAPPC14).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Trafficking protein particle complex subunit 14 (TRAPPC14).