Trafficking protein particle complex subunit 2 (TRAPPC2)

Trafficking protein particle complex subunit 2 (TRAPPC2) is a component of the TRAPP complex, a multisubunit tethering complex involved in the targeting and fusion of endoplasmic reticulum-to-Golgi transport vesicles. TRAPPC2 (also called sedlin) is required for the export of large cargoes such as procollagen from the endoplasmic reticulum, enabling their subsequent modification in the Golgi apparatus. Mutations in the TRAPPC2 gene cause X-linked spondyloepiphyseal dysplasia tarda, a disease characterized by impaired bone and cartilage development, typically manifesting in males during childhood. TRAPPC2 can interact with proteins such as MBP-1 and Alpha-enolase (ENO1) and may inhibit the transcriptional repression and pro-apoptotic functions of ENO1. No evidence was found that this protein is a direct therapeutic target, nor that any clinically used drugs modulate it.

Other names

MBP-1-interacting protein 2AMIP-2ASEDLSEDTTRAPPC2P1TRS20ZNF547LhYP38334sedlin