Trafficking protein particle complex subunit 2B (TRAPPC2B)

Trafficking protein particle complex subunit 2B (TRAPPC2B) is a component of the TRAPP (trafficking protein particle) complex, which is involved in vesicular transport, particularly from the endoplasmic reticulum to the Golgi apparatus[1][3][5][9]. The protein binds to transcriptional corepressors and may inhibit cell death mediated by the enzyme ENO1[3][5][6][9]. In humans, the TRAPPC2B gene has been described as a transcribed retropseudogene, raising uncertainty as to whether it produces a functional protein product or not[2]. TRAPPC2B is not recognized as a therapeutic target (such as a receptor, enzyme, or transporter) in current literature[3][7]. Mutations in related genes can be associated with spondyloepiphyseal dysplasia tarda, but disease relevance of TRAPPC2B specifically is unclear[3][5]. **Note:** This target is problematic: - TRAPPC2B is sometimes documented as a transcribed retropseudogene in humans and may not encode a functional protein[2]. - It is not established as a canonical therapeutic target—no known drugs target TRAPPC2B, and no clinical mechanism of action or biomarkers are associated. - Most functional data refer to its role as a complex subunit rather than as a direct druggable protein.

Other names

MIP-2ASEDLP1TRAPPC2P1SEDLPMBP-1-interacting protein 2AMIP2A