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Trafficking protein particle complex subunit 3 (TRAPPC3)
- Target
- TRAPPC3
- Molecular classification
- Other (subunit of multi-protein tethering complex), Vesicle-trafficking protein
01
Overview
Trafficking protein particle complex subunit 3 (TRAPPC3) is a protein encoded by the TRAPPC3 gene in humans. It is a component of the trafficking protein particle (TRAPP) complex, which is involved in the tethering of transport vesicles to the cis-Golgi membrane and regulates transport from the endoplasmic reticulum to the Golgi apparatus. TRAPPC3 functions primarily as part of a multi-subunit complex essential for vesicular transport within the secretory pathway. It is not considered a typical therapeutic target (such as an enzyme, receptor, or transporter) but plays a critical role in intracellular protein trafficking. Mutations or dysfunction in TRAPPC3 have been associated with rare genetic diseases, particularly ciliopathies.
- Other names
- BET3BET3 homologCDABP0066trafficking protein particle complex 3
02
Biological functions
Vesicle transportTethering of transport vesicles to the cis-Golgi membraneRegulation of endoplasmic reticulum (ER) to Golgi apparatus protein transport
03
Disease associations
ciliopathies (such as ciliary dyskinesia, primary, 39 and Senior-Loken syndrome 7)Other (implicated in vesicular trafficking disorders)
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