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Trafficking protein particle complex subunit 5 (TRAPPC5)
- Target
- TRAPPC5
- Molecular classification
- Other (vesicular trafficking complex subunit, multisubunit tethering complex component)
01
Overview
Trafficking protein particle complex subunit 5 (TRAPPC5) is a conserved core subunit of the TRAPP complexes, instrumental in the regulation and tethering of ER-to-Golgi vesicular transport and GEF activity for selected Rab GTPases, with links to rare genetic diseases through TRAPP complex dysfunction.
- Other names
- TRAPPC5Trs31MGC52424trafficking protein particle complex subunit 5trafficking protein particle complex 5
02
Biological functions
Endoplasmic reticulum to Golgi vesicle-mediated transportmembrane traffickingcomponent of multisubunit tethering complexindirect Rab GEF activity
03
Disease associations
Binocular vision diseasespondyloepiphyseal dysplasia tardaother rare genetic disease
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