Trafficking protein particle complex subunit 6A (TRAPPC6A)

Trafficking protein particle complex subunit 6A (TRAPPC6A) is a core component of the TRAPP (Trafficking Protein Particle) complexes, which mediate tethering of transport vesicles to the cis-Golgi membrane and regulate intracellular protein trafficking between the endoplasmic reticulum and Golgi apparatus[1][3]. TRAPPC6A acts primarily as a structural subunit, interacting with other components to stabilize the formation of higher-order TRAPP complexes (TRAPPII, TRAPPIII), critical for normal vesicular trafficking[1]. TRAPPC6A is a target for ubiquitination and normally degraded by the proteasome; mutations or aggregation of TRAPPC6A have been linked to neurological disorders such as intellectual disability as well as to neurodegenerative diseases like Alzheimer’s disease, where it has been found to aggregate and potentially drive Tau and amyloid pathology in conjunction with loss of WWOX[1][2]. Differential expression and dysfunction of TRAPPC6A have been associated with certain forms of heart failure, indicating a role in cardiovascular disease as well[1]. There are no known drugs that directly target TRAPPC6A, and it is not considered a canonical therapeutic target (such as a receptor, enzyme, or channel); its pathogenic and biomarker roles derive instead from its protein trafficking and aggregation properties.

Other names

TRAPPC6ATRS33Trafficking protein particle complex 6ATRAPPC6AΔTPC6AHSPC289MGC2650