Trafficking regulator of GLUT4 1 (TRARG1)

Trafficking regulator of GLUT4 1 (TRARG1) is a transmembrane protein localized to GLUT4 storage vesicles in adipose and muscle tissues, where it positively regulates the trafficking and recycling of the glucose transporter GLUT4 (SLC2A4), thereby facilitating insulin-stimulated glucose uptake[1][2][3][4]. TRARG1 has a unique membrane topology: its N-terminus is cytosolic and its C-terminus has a short luminal/extracellular segment, with one transmembrane domain spanning residues 145–172 and a re-entrant loop between residues 101–127[1][2]. The protein is a member of the dispanin family and is considered to have tumor suppressor properties (previously annotated as TUSC5), with disease association including cancer and certain metabolic syndromes[4]. TRARG1 is not essential for initial GLUT4 membrane fusion on short insulin stimulation, but is critical for continued recycling and maintenance of glucose transport during prolonged insulin signaling[4]. Limited information is currently available regarding specific drug interactions, mechanisms of action, biomarker utility, or therapeutic safety concerns with TRARG1.

Other names

TUSC5Interferon-induced transmembrane domain-containing protein D3Interferon induced transmembrane protein domain containing 3Protein located at seventeen-p-thirteen point three 1Located at seventeen p thirteen point three 1Brain endothelial cell derived gene-1Dispanin subfamily B member 1DSPB1BEC-1IFITMD3LOST1