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TRAIL Pathway
- Target
- TRAIL Pathway
- Molecular classification
- Signaling pathway, Apoptosis pathway
01
Overview
The TRAIL pathway refers to the signaling cascade initiated by the Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL). This pathway is primarily known for its ability to induce apoptosis selectively in tumor cells while sparing most normal cells, making it a significant target for cancer therapy.
- Other names
- TNF-related apoptosis-inducing ligand pathwayTRAIL signaling cascade
02
Mechanism of action
Activation of death receptors (DR4/DR5), DISC formation, caspase activation, apoptosis induction.
03
Biological functions
Apoptosis inductionImmune regulationSignal transductionCell death
04
Disease associations
Cancer
05
Safety considerations
Potential toxicity towards normal tissuesDevelopment of resistance mechanisms (e.g., decoy receptor overexpression, FLIP overexpression)Off-target effects
06
Interacting drugs
Recombinant TRAIL
1 more in the full profile.
07
Biomarkers
Expression levels of DR4 and DR5Expression levels of decoy receptors (DcR1, DcR2, OPG)FLIP expressionCaspase activation
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