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Target intelligence / Profile preview
Trans-epidermal Water Loss (TEWL)
- Target
- TEWL
- Molecular classification
- Physiological Parameter, Biophysical Process
01
Overview
Trans-epidermal water loss (TEWL) is the process by which water passively evaporates from the skin’s surface into the surrounding environment. It is a physiological phenomenon that occurs continuously and serves as an important indicator of skin barrier function. TEWL specifically refers to the amount of water that escapes through the stratum corneum, which is the outermost layer of the epidermis. Maintaining optimal hydration supports both appearance and function of healthy skin barriers.
02
Mechanism of action
N/A - TEWL is a process, not a target for drug action. Interacting substances either increase water content (humectants) or decrease water evaporation (occlusives).
03
Biological functions
Regulation of skin hydrationMaintenance of skin barrier functionPassive water transport
04
Disease associations
EczemaPsoriasisAtopic DermatitisDry SkinSkin barrier dysfunction
05
Safety considerations
Excessive TEWL leading to skin dryness and irritationCompromised skin barrier increasing susceptibility to irritants and allergens
06
Interacting drugs
Humectants (hyaluronic acid, glycerin, urea, vitamin B5)
1 more in the full profile.
07
Biomarkers
TEWL measurement as indicator of skin barrier integrity
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