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Transcription-Coupled Nucleotide Excision Repair Pathway (TC-NER)
- Target
- TC-NER
- Molecular classification
- DNA Repair Pathway, Cellular Pathway
01
Overview
Transcription-coupled nucleotide excision repair (TC-NER) is a specialized subpathway of nucleotide excision repair (NER) that specifically targets and rapidly repairs DNA lesions blocking RNA polymerase II progression during transcription on the transcribed strand of active genes. This pathway ensures gene expression resumes quickly after damage, maintaining cellular function and viability.
- Other names
- Transcription-Coupled RepairTCRRNA polymerase II-directed DNA repair
02
Biological functions
DNA repairTranscription fidelityGenome maintenanceResponse to DNA damageRegulation of gene expression
03
Disease associations
Cockayne SyndromeCancerAgingUV sensitivity
04
Safety considerations
Defects in TC-NER lead to genetic disorders and increased cancer risk.Over-activation can lead to hyper-repair and genomic instability.
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