Target intelligence / Profile preview

Transcription elongation factor A like 6 (TCEAL6)

Target
TCEAL6
Molecular classification
Transcription elongation factor, Transcription factor (functionally related family), Nucleic acid-binding protein, Other (TCEAL family)
01

Overview

Transcription elongation factor A like 6 (TCEAL6) is a member of the TCEAL gene family, which encodes proteins related to transcriptional elongation factor SII (TFIIS/SII) and is involved in the regulation of RNA polymerase II transcriptional activity[7][9]. The exact function of TCEAL6 remains unclear, but it is predicted to contribute to nuclear transcriptional regulation, potentially by modulating transcript elongation and processing steps. TCEAL6 is localized to the nucleus and its gene is found on the X chromosome (X:102,140,476-102,142,970)[6][7]. The protein is not currently implicated as a direct target for drug intervention, nor is it a clinically established biomarker. Its role in disease remains under investigation, with limited evidence for correlative expression changes in certain cancers[3][7].

Other names
Transcription elongation factor A like 6TCEAL6WEX2Transcription elongation factor S-II protein-like 6Transcription elongation factor A protein-like 6Transcription elongation factor A (SII)-like 6TCEA-like protein 6Tceal3 (possible confusion/alias in some sources)
02

Mechanism of action

None. There are no drugs targeting this molecule, so no mechanisms of drug action are reported.

03

Biological functions

Regulation of transcriptional elongationModulation of RNA polymerase II activity[1][7][9]Broadly, involvement in transcriptional control
04

Disease associations

Possible involvement in cancer (correlative roles in glioblastoma multiforme expression studies, but not a validated driver)[3]Described in connection with Severe congenital neutropenia 7 and Pelizaeus-Merzbacher disease[7]No direct disease-causative evidence or established mechanism

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