Transcription elongation factor A protein 1 (TCEA1)

Transcription elongation factor A protein 1 (TCEA1) is a ubiquitously expressed transcription elongation factor essential for efficient RNA polymerase II-mediated transcription elongation, especially at template-encoded arrest sites where elongating RNA polymerases can become stalled. TCEA1 (also known as TFIIS) stimulates RNA polymerase II to cleave nascent RNA, thereby resolving transcriptional backtracking and enabling productive elongation. TCEA1 plays central roles in gene expression regulation, myeloid cell proliferation, differentiation, and apoptosis, and is implicated as a regulator in hematopoietic cell development. Its dysfunction is linked to disorders such as Cockayne syndrome, anemia, and may influence susceptibility to malignancies due to its regulatory effect on differentiation and cell survival pathways[1][2][3]. Key points to note: - TCEA1 is not typically considered a direct therapeutic target (e.g., not a receptor or enzyme targeted by drugs), but it has a notable role in disease, especially in genetic syndromes and cancer[1][2]. - No known clinically approved drugs target TCEA1 directly, nor are there established mechanisms of action or clinical biomarkers associated with its inhibition or modulation[1][2][3]. - TCEA1 is a specific gene/protein and the names provided are correct and reflect established nomenclature[1][3].

Other names

Transcription elongation factor A1GTF2SSIITCEATF2STFIISTranscription elongation factor II Stranscription factor IISTranscription elongation factor S-II protein 1Transcription elongation factor TFIIS.o