Transcription elongation factor A protein-like 1 (TCEAL1)

Transcription elongation factor A protein-like 1 (TCEAL1) is a nuclear phosphoprotein belonging to the transcription elongation factor A (SII)-like (TCEAL) gene family, encoded on the human X chromosome at Xq22.2[1][3]. It modulates transcription in a promoter context-dependent manner, likely through protein-protein interactions with other transcriptional regulators rather than direct DNA binding[1][3]. The protein contains a zinc finger-like motif and a sequence related to the Pol II-binding region of transcription factor SII[1][3]. Variants in TCEAL1 have recently been implicated in neurodevelopmental disorders characterized by developmental delay, intellectual disability, autism spectrum disorder-like behaviors, hypotonia, gait abnormalities, and mild craniofacial dysmorphism[2][7]. The full disease spectrum is still being defined, but TCEAL1 appears to be essential for proper transcriptional regulation in neurons and other cell types[1][2][7].

Other names

TCEAL1SIIRTCEA-like protein 1p21pp21WEX9nuclear phosphoprotein p21/SIIRtranscription elongation factor S-II protein-like 1HIJRSNEDGFAX