Transcription elongation factor A protein-like 7 (TCEAL7)

Transcription elongation factor A protein-like 7 (TCEAL7) is a nuclear phosphoprotein and a member of the transcription elongation factor A (SII)-like family, sharing homology with TFIIS/TCEA1. TCEAL7 acts as a context-dependent transcriptional regulator that modulates the activity of promoter elements, particularly influencing cell proliferation and differentiation processes[1][3]. In cancer biology, TCEAL7 functions as a tumor suppressor; its downregulation is frequently observed in a variety of human cancers, including ovarian cancer, where this loss promotes anchorage-independent growth and deregulates transcriptional activity of c-Myc, leading to increased expression of cell cycle regulators like cyclin D1 and ornithine decarboxylase[1]. In muscle tissue, TCEAL7 is muscle lineage-restricted during development and contributes to skeletal muscle differentiation by repressing myoblast proliferation and promoting myogenic differentiation, in part through interaction with and inhibition of Cdk1 kinase activity[2][3]. The TCEAL7 gene is dynamically regulated during muscle regeneration and is responsive to myogenic regulatory factors, which regulate its promoter activity via E-box motifs[3]. Loss or dysregulation of TCEAL7 is thus implicated both in tumorigenesis and muscle development abnormalities. There are currently no documented direct drug interactions or established mechanisms of action for therapeutic agents targeting TCEAL7.

Other names

Transcription elongation factor A (SII)-like 7TCEA-like protein 7Transcription elongation factor S-II protein-like 7WEX5MGC23947